Operational Usability Evaluation of the LIAISON® QuantiFERON®-TB Gold Plus Solution in a High Volume Laboratory Setting.

BACKGROUND: Screening for latent tuberculosis infection (LTBI) using interferon gamma release assays has become commonplace for a variety of reasons. Given the high test volume, automated platforms are highly desired. METHODS: To this end, we performed an operational usability study using a newly FDA-approved, fully automated, random-access platform. RESULTS & CONCLUSIONS: Our results showed that this platform can save time and labor and will be a potential useful addition to streamline LTBI screening. Studies to verify performance characteristics are warranted.

Detection of type-specific antibodies to HSV-1 and HSV-2: comparative analysis of a chemiluminescence immunoassay with a conventional ELISA.

Type-specific serologic tests for human herpes simplex virus (HSV) are critically important for sexually transmitted disease evaluation. We compared the LIAISON® HSV-1 and HSV-2 Type Specific assays relative to an established commercial ELISA. The overall agreement of the chemiluminescence immunoassay versus the ELISA assay was 99.6% (HSV-1) and 100% (HSV-2). The LIAISON® methodology has several advantages.